王慧婧 特聘副研究员
单位:金沙威尼斯欢乐娱人城 药物化学系
通讯地址:成都市人民南路三段17号金沙威尼斯欢乐娱人城610041
E-mail: hjwang0313@scu.edu.cn, hjwang0313@163.com
教育与工作经历:
2008.09-2012.06 金沙威尼斯欢乐娱人城 理学学士
2012.09-2017.06 重庆大学创新药物研究中心 工学博士(导师:秦勇教授)
2017.09-2019.12 美国加州大学圣地亚哥分校(UCSD) 博士后(导师:Dionicio Siegel教授)
2020.04-至今 金沙威尼斯欢乐娱人城药物化学系,特聘副研究员
研究方向:
1. 手性药物的不对称合成
2. 生物酶的理性设计及其在药物合成中的应用
科研项目:
1. 国家自然科学基金青年科学基金,天然核苷及类似物的立体发散性合成研究,项目号:22201192,2023-2025,负责人;
2. 四川省自然科学基金面上项目,单加氧酶的理性设计助力长春胺类生物碱的精准合成,项目号:2022NSFSC0615,2022-2023,负责人;
3. 2020-2023 金沙威尼斯欢乐娱人城引进人才科研启动经费资助项目,负责人。
曾获奖项:
1、2022年入选四川省青年人才计划(天府峨眉计划)
2、2021年课堂教学质量优秀奖
发表论文:
1. Qi Wang, Jiayi Mu, Jie Zeng, Linxi Wan, Yangyang Zhong, Qiuhong Li, Yitong Li, Huijing Wang*, and Fener Chen*. Additive-controlled asymmetric iodocyclization enables enantioselective access to both a- and b-nucleosides. Nat. Common. 2023, 14, 138. (一区,IF 17.694);
2. Hui-Jing Wang, Yang-Yang Zhong, You-Cai Xiao* and Fen-Er Chen*. Chemical and chemoenzymatic stereoselective synthesis of β-nucleosides and their analogues. Org. Chem. Front. 2022, 9, 1719−1741 (一区,IF 5.281);
3. Junxia Wei, Huijing Wang (co-first author), Qinwen Zheng, Jifa Zhang, Zhichao Chen, Jiaxing Wang, Liang Ouyang, Yuxi Wang*.Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers. Eur. J. Med. Chem. 2022, 241, 114650 (一区,IF 7.088).
4. Huijing Wang, Qiuyan Dong, Qinxia Xie, Pei Tang*. Asymmetric synthesis of ABC tricyclic systems in Daphniphyllum alkaloid. Chin. Chem. Lett. 2020, 31, 685-688. (一区,IF 8.455);
5. Huijing Wang, Matthew J. Kolar, Tina Chang, José Rizo, Srihari Konduri, Clare McNerlin, Alan Saghatelian, and Dionicio Siegel*. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Org. Lett. 2019, 21, 8080−8084. (一区,IF 6.072);
6. Yan-zhao Liu, Yao Hu, Guang-hui Lv, Rui-fang Nie, Yao Peng, Chen Zhang, Song-yang Lv, Li Hai, Hui-jing Wang*, and Yong Wu*. Synthesis of 1,2-Benzothiazines via C−H Activation/Cyclization in a Recyclable, Mild System. ACS Sustainable Chem. Eng. 2019, 7, 13425−13429. (一区,IF 8.198);
7. Hongmin Qu, Yu Chen, Xiangling Ceng, Pei Tang, Huijing Wang* and Fen-Er Chen*. Enantioselective synthesis of chiral 3-alkynyl-3-hydroxyindolin-2-ones by Zn/bis(sulfonamide)-diamine catalyzed asymmetric addition of alkynes to isatins. Asian J. Org. Chem. 2022, 11, e202200188 (1 of 5) (三区,IF 3.116);
8. Yi Luo, Lingmei Guo, Xinling Yu, Haosheng Ding, Huijing Wang*, and Yong Wu*. Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2- aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C–H Bond Activation. Eur. J. Org. Chem. 2019, 3203–3207. (三区,IF 3.261);
9. Huijing Wang, Pei Tang, Qilong Zhou, Dan Zhang*, Zhitao Chen, Hongxiu Huang, Yong Qin*. One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (-)-Nephrosteranic Acid, J. Org. Chem. 2015, 80, 2494-2505. (二区,IF 4.198)
10. Hongxiu Huang, Huijing Wang (co-first author), Ling Tan, Shuqing Wang, Pei Tang, Hao Song*, Xiao-Yu Liu, Dan Zhang, Yong Qin*. Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Synthesis of Chiral Pyrazolidinone Derivatives, J. Org. Chem. 2016, 81, 10506-10516. (二区,IF 4.198)
编辑:金沙威尼斯欢乐娱人城