药物化学系

王慧婧 特聘副研究员

来源: 发布时间:2020年08月14日 点击数:

王慧婧 特聘副研究员      

单位:金沙威尼斯欢乐娱人城 药物化学系

通讯地址:成都市人民南路三段17号金沙威尼斯欢乐娱人城610041

E-mail: hjwang0313@scu.edu.cn, hjwang0313@163.com


教育与工作经历:

2008.09-2012.06 金沙威尼斯欢乐娱人城 理学学士

2012.09-2017.06 重庆大学创新药物研究中心 工学博士(导师:秦勇教授)

2017.09-2019.12 美国加州大学圣地亚哥分校(UCSD 博士后(导师:Dionicio Siegel教授)

2020.04-至今 金沙威尼斯欢乐娱人城药物化学系,特聘副研究员


研究方向:

1. 手性药物的不对称合成

2. 生物酶的理性设计及其在药物合成中的应用


科研项目:

1. 国家自然科学基金青年科学基金,天然核苷及类似物的立体发散性合成研究,项目号:222011922023-2025,负责人;

2. 四川省自然科学基金面上项目,单加氧酶的理性设计助力长春胺类生物碱的精准合成,项目号:2022NSFSC06152022-2023,负责人;

3. 2020-2023 金沙威尼斯欢乐娱人城引进人才科研启动经费资助项目,负责人。


曾获奖项:

12022年入选四川省青年人才计划(天府峨眉计划)

22021年课堂教学质量优秀奖


发表论文:

1. Qi Wang, Jiayi Mu, Jie Zeng, Linxi Wan, Yangyang Zhong, Qiuhong Li, Yitong Li, Huijing Wang*, and Fener Chen*. Additive-controlled asymmetric iodocyclization enables enantioselective access to both a- and b-nucleosides. Nat. Common. 2023, 14, 138. (一区,IF 17.694)

2. Hui-Jing Wang, Yang-Yang Zhong, You-Cai Xiao* and Fen-Er Chen*. Chemical and chemoenzymatic stereoselective synthesis of β-nucleosides and their analogues. Org. Chem. Front. 2022, 9, 1719−1741 (一区,IF 5.281);

3. Junxia Wei, Huijing Wang (co-first author), Qinwen Zheng, Jifa Zhang, Zhichao Chen, Jiaxing Wang, Liang Ouyang, Yuxi Wang*.Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers. Eur. J. Med. Chem. 2022, 241, 114650 (一区,IF 7.088).

4. Huijing Wang, Qiuyan Dong, Qinxia Xie, Pei Tang*. Asymmetric synthesis of ABC tricyclic systems in Daphniphyllum alkaloid. Chin. Chem. Lett. 2020, 31, 685-688. (一区,IF 8.455)

5. Huijing Wang, Matthew J. Kolar, Tina Chang, José Rizo, Srihari Konduri, Clare McNerlin, Alan Saghatelian, and Dionicio Siegel*. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Org. Lett. 2019, 21, 8080−8084. (一区,IF 6.072)

6. Yan-zhao Liu, Yao Hu, Guang-hui Lv, Rui-fang Nie, Yao Peng, Chen Zhang, Song-yang Lv, Li Hai, Hui-jing Wang*, and Yong Wu*. Synthesis of 1,2-Benzothiazines via C−H Activation/Cyclization in a Recyclable, Mild System. ACS Sustainable Chem. Eng. 2019, 7, 13425−13429. (一区,IF 8.198)

7. Hongmin Qu, Yu Chen, Xiangling Ceng, Pei Tang, Huijing Wang* and Fen-Er Chen*. Enantioselective synthesis of chiral 3-alkynyl-3-hydroxyindolin-2-ones by Zn/bis(sulfonamide)-diamine catalyzed asymmetric addition of alkynes to isatins. Asian J. Org. Chem. 2022, 11, e202200188 (1 of 5) (三区,IF 3.116)

8. Yi Luo, Lingmei Guo, Xinling Yu, Haosheng Ding, Huijing Wang*, and Yong Wu*. Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2- aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C–H Bond Activation. Eur. J. Org. Chem. 2019, 3203–3207. (三区,IF 3.261)

9. Huijing Wang, Pei Tang, Qilong Zhou, Dan Zhang*, Zhitao Chen, Hongxiu Huang, Yong Qin*. One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (-)-Nephrosteranic Acid, J. Org. Chem. 2015, 80, 2494-2505. (二区,IF 4.198)

10. Hongxiu Huang, Huijing Wang (co-first author), Ling Tan, Shuqing Wang, Pei Tang, Hao Song*, Xiao-Yu Liu, Dan Zhang, Yong Qin*. Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Synthesis of Chiral Pyrazolidinone Derivatives, J. Org. Chem. 2016, 81, 10506-10516. (二区,IF 4.198)

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