旷喜 副教授
单位:金沙威尼斯欢乐娱人城药理系
通讯地址:成都市人民南路三段十七号金沙威尼斯欢乐娱人城华西药学大楼503室
电话:(028)85501381
E-mail:kuangxi56@163.com
教育经历:
2008/2 -2009/2 美国Mayo Clinic Foundation (梅约医学中心) 生物化学与分子生物学系,联合培养博士生
2003/9 – 2009/2 金沙威尼斯欢乐娱人城,药理学, 硕博连读,博士
1998/9– 2002/7 金沙威尼斯欢乐娱人城, 药学, 学士。
研究与学术工作经历:
2014/7 – 至今 金沙威尼斯欢乐娱人城,金沙威尼斯欢乐娱人城, 药理系,副教授
2009/7 – 2014/6 金沙威尼斯欢乐娱人城,金沙威尼斯欢乐娱人城, 药理系,讲师
研究方向:
1. 心脑血管分子药理
2. 神经退行性疾病
主要研究课题:
1.MEOX2基因调控的血管性因素与阿尔兹海默病病理机制的相关性研究(国家自然基金青年基金项目,项目批准号81202540,2013-2015,项目负责人)
2. 阿尔兹海默病潜在治疗靶点—基质金属蛋白酶的作用研究 (金沙威尼斯欢乐娱人城青年教师科研启动基金项目,项目批准号2009SCU11180, 2010-2011,项目负责人)
3.藁本内酯调控缺血性脑卒中神经炎性的分子机制(国家自然基金面上项目,项目批准号81072636,2011-2013,主研)
近年发表论文:
1. Xi Kuang, Liang-Fen Wang, Lu Yu, Yong-Jie Li, Yan-Nan Wang, Qian He, Chu Chen, Jun-Rong Du. Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling. Free Radical Biology and Medicine 2014 (71):165-175.
2. Xi Kuang,Ya-Shu Chen, Liang-Fen Wang, Yong-jie Li, Ke Liu, Men-Xue Zhang, Liang-Jiao Li, Chu Chen, Qian He, Yu Wang, Jun-Rong Du . Klothoupregulation contributes to the neuroprotection of ligustilide in an Alzheimer’s disease mouse model. Neurobiology of Aging 2014 (35):169-178.
3. Xi Kuang, Jun-Rong Du, Ya-Shu Chen, Jing Wang, Yan-Nan Wang . Protective effect of Z-ligustilide against amyloid β-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains . Pharmacology, Biochemistry and Behavior 2009 (92):635-641.
4. Long FY, Chen YS, Zhang L,Kuang X, Yu Y, Wang LF, Liu XJ, Wang L, Zhou YF, Sang N, Du JR.Pennogenyl saponins induce cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.J Ethnopharmacol. 2015 13;162:112-20.
5.Li YJ, Li XH, Wang LF, Kuang X, Hang ZX, Deng Y, Du JR.Therapeutic efficacy of a novel non-peptide αvβ3 integrin antagonist for pathological retinal angiogenesis in mice.Exp Eye Res. 2014 Dec;129:119-26.
6.Yu L, Chen C, Wang LF, Kuang X, Liu K, Zhang H, Du JR.Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke.PLoS One. 2013;8(2):e55839.