贾知军 研究员（博士生导师）
单 位：金沙威尼斯欢乐娱人城第二医院，金沙威尼斯欢乐娱人城
通信地址：成都市人民南路三段十七号金沙威尼斯欢乐娱人城
E-mail： zhijun_jia@scu.edu.cn
简历：
2020-至今 金沙威尼斯欢乐娱人城，研究员
2018-2020 美国加州理工学院，博士后，师从Frances H. Arnold教授（2018诺贝尔化学奖）
2017-2018 德国马克斯•普朗克分子生理所，博士后，师从Herbert Waldmann教授
2012-2016 德国多特蒙德工业大学化学生物学专业，博士，师从Herbert Waldmann教授
2009-2012 金沙威尼斯欢乐娱人城药物化学专业，硕士，师从陈应春教授
2005-2009 金沙威尼斯欢乐娱人城生命科学院生物技术基地班，本科
研究方向：
综合利用定向进化和从头设计策略，创造非天然的酶功能，从而发展手性药物绿色制造的新方法，以及儿童疾病预防、诊断和治疗的新手段。
本课题组常年招收博士后，要求具有有机化学、生物学、材料学、生物工程等相关专业背景的博士学位，具体面议。
发表论文情况：
17. Jia, Z.-J., Gao, S., Arnold, F. H.,* Enzymatic Primary Amination of Benzylic and Allylic C(sp3)–H Bonds. J. Am. Chem. Soc., 2020, DOI: 10.1021/jacs.0c03428.
16. Cho, I., Prier, C. K., Jia, Z.-J., Zhang, R. K., Görbe, T., Arnold, F. H.,* Enantioselective Aminohydroxylation of Olefins Catalyzed by an Engineered Hemoprotein. Angew. Chem. Int. Ed. 2018, 58, 3138-3142.
15. Jia, Z.-J., Shan, G., R., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis. Angew. Chem. Int. Ed. 2018, 57, 14493-14497.
14. Jia, Z.-J., Takayama, H., Futamura, Y., Aono, H., Bauer, J. O., Strohmann, C., Antonchick, * A. P., Osada, * H., Waldmann, H.* Catalytic Enantioselective Synthesis of a Pyrrolizidine–Alkaloid-Inspired Compound Collection with Antiplasmodial Activity. J. Org. Chem. 2018, 13, 7033-7041.
13. Jia, Z.-J., Merten, C., Knauer, L., Murarka, S., Strohmann, C., Waldmann, H.* Biology-Oriented Synthesis of Decahydro-4,8-epoxyazulene Scaffolds. Synlett 2017, 28, 2918-2922.
12. Jia, Z.-J., Merten, C., Gontla, R., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* General Enantioselective C‒H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angew. Chem. Int. Ed. 2017, 56, 2429-2434.
11. Murarka, S., Jia, Z.-J., Merten, C., Daniliuc C.-G., Antonchick, A. P.,* Waldmann, H.* Rhodium(II)-Catalyzed Enantioselective Synthesis of Troponoids. Angew. Chem. Int. Ed. 2015, 54, 7653-7656.
10. Jia, Z.-J., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* Phosphine-Catalyzed Dearomatizing [3+2] Annulations of Isoquinolinium Methylides with Allenes. Chem Commun. 2015, 51, 1054-1057.
9. Takayama, H., Jia, Z.-J., Kremer, L., Bauer J. O., Strohmann, C., Ziegler, S., Antonchick, A. P.,* Waldmann, H.* Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid-Inspired Compound Collection. Angew. Chem. Int. Ed. 2013, 52, 12404-12408.
8. Ma, C., Jia, Z.-J., Liu, J.-X, Zhou, Q.-Q., Dong, L., Chen, Y.-C.* A Concise Assembly of Electron-Deficient 2,4-Dienes and 2,4-Dienals: Regio- and Stereoselective exo-Diels–Alder and Redox Reactions through Sequential Amine and Carbene Catalysis. Angew. Chem., Int. Ed. 2013, 52, 948-951.
7. Jia, Z.-J., Jiang, K., Zhou, Q.-Q., Dong, L., Chen, Y.-C.* Amine-N-Heterocyclic Carbene Cascade Catalysis for the Asymmetric Synthesis of Fused Indane Derivatives with Multiple Chiral Centres. Chem. Commun. 2013, 49, 5892-5894.
6. Jia, Z.-J., Zhou, Q., Zhou, Q.-Q., Chen, P.-Q., Chen, Y.-C.* exo-Selective Asymmetric Diels–Alder Reaction of 2,4-Dienals and Nitroalkenes by Trienamine Catalysis. Angew. Chem., Int. Ed. 2011, 50, 8638-8641.
5. Jia, Z.-J., Jiang, H., Li, J.-L., Gschwend, B., Li, Q.-Z., Yin, X., Grouleff, J., Chen, Y.-C.,* Jørgensen, K. A.* Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions. J. Am. Chem. Soc. 2011, 133, 5053-5061.
4. Jiang, K., Jia, Z.-J., Yin, X., Wu, L., Chen, Y.-C.* Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif. Org. Lett. 2010, 12, 2766-2769.
3. Jiang, K., Jia, Z.-J., Chen, S., Wu, L., Chen, Y.-C.* Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation. Chem. Eur. J. 2010, 16, 2852-2856.
2. Xiong, X.-F., Jia, Z.-J., Du, W., Jiang, K., Liu, T.-Y., Chen, Y.-C.* Merging Chiral Organocatalysts: Enantio- and Diastereoselective Direct Vinylogous Mannich Reaction of Alkylimines. Chem. Commun. 2009, 6994-6996.
1. Narayan, R., Potowski, M., Jia, Z.-J., Antonchick, A. P.,* Waldmann, H.* Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis. Acc. Chem. Res. 2014, 47, 1296-1310.
