Professor of Pharmaceutics, Doctoral Supervisor
Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education
Department of Pharmaceutics, West China School of Pharmacy, Sichuan University
Ad: No.17 People’s South Road, Chengdu 610041, China
Tel/Fax: +86-28-85501566; +86-28-85501615
Email: zrzzl@vip.sina.com
Research Interests
Drug targeting and drug delivery systems.
Bio
1982, Sichuan Medical College, BS in Pharmacy
1982 – 1988, Research Assistant and Lecturer, Department of Instrumental Analysis, School of Pharmacy, West China University of Medical Sciences.
1993, West China University of Medical Science, PhD in Pharmaceutical Science.
1993, Associate professor in Pharmaceutics, Vice Dean of School of Pharmacy, West China University of Medical Sciences.
1997, Full professor in Pharmaceutics, School of Pharmacy, West China University of Medical Sciences.
1998, Doctoral supervisor.
1999 – 2017, Dean of West China School of Pharmacy, Sichuan University (previously West China University of Medical Sciences).
1999, recipient of the National Distinguished Youth Scientific Fund.
2000, recipient of the Hundreds and Thousands of Talents Project.
Professional Affiliations
Member of Academic Degrees Committee of the State Council of China (2005-2015).
Member of Chinese Pharmacopoeia Commission and Director of Pharmaceutical adjutants & Drug packaging materials of Chinese Pharmacopoeia Commission（1996-2022）.
Member of Expert Consultation Group in the field of Health Sciences, National Basic Research Program of China (973 Program).
Member of Review Expertise Group of National Natural Science Foundation of China (NSFC).
Director of Editorial board of pharmaceutical textbooks for national advanced medical colleges, Science Publishing House.
Deputy Director of the Review Committee of pharmaceutical textbooks for national advanced colleges, People's Health Publishing House.
Vice Chairman of Pharmaceutical Education Research Association, China Higher Medical Education Association.
Editor-in-Chief of West China Journal of Pharmaceutical Sciences and Journal of Chinese Pharmaceutics.
Deputy Editor-in-Chief of "Chinese Traditional and Herbal Drugs" and "Chinese Pharmaceutical Yearbook".
Member of editorial board for Acta Pharmaceutica Sinica, Chinese Pharmaceutical Journal, Chinese Journal of Pharmaceuticals and Asian Journal of Pharmaceutical Sciences.
Research Achievements
Prof. Zhang’s group has done great works on the development of drug delivery systems, especially in targeted drug delivery, novel drug and formulation development. Over the past decades, Prof. Zhang has been in charge of over twenty research projects, receiving financial supports from the National Distinguished Youth Scientific Fund, National Natural Science Foundation of China, National High-Tech Research and Development Project (863 Project), the National Eleventh Five-Year Plan High-Tech fundamental research on drug discovery, Ministry of Education and Sichuan province.
Prof. Zhang supervised 19 postdoctoral fellows, over 70 PhD students and 96 MS students.
Prof. Zhang has contributed to 12 monographs and book chapters, published more than 400 research papers including Nature Communications, Advanced Materials, Cell Research and etc. He received the approval of 15 patents in China, was awarded with the second prize of the National Scientific and Technological Progress Award (first completer), and was awarded the First-Prize of Sichuan Provincial Science and Technology Improvement (5 times), and also the First-Prize of nature Science of Ministry of Education（1 times）. He conducted the research of three new drugs that have been indexed in the Chinese Pharmacopoeia and the National Essential Medicines List.
Research Projects in recent five years
1. Investigation on drug delivery system targeting renal tubular epithelial cells for treatment of chronic kidney disease. Joint Fund of Regional Innovation Development, National Natural Science Foundation of China (U20A20411), 2021.1-2024.12, 2,600,000 RMB.
2. Highly-efficient biomacromolecular drug delivery system. Key Project of National Natural Science Foundation of China (81690260), 2017.1～2021.12, 17,238,800 RMB.
3. Study of pancreas and lung double-organ targeted drug delivery system for acute pancreatitis. National Natural Science Foundation of China (81473169), 2015.1～2018.12; 1,100,000 RMB.
4. Development of Novel Drug Formulations and Preparations, Chongqing Yaoyou Pharmaceutical Co Ltd, 2010.1～2019.12,10,000,000 RMB.
Selected Publications from 2015
1. SQ Huang, L Deng, HM Zhang, LY Wang, YC Zhang, Q Lin, T Gong, X Sun, ZR Zhang*, L Zhang*. Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment. Nano Research, 2022, 15:728-737.
2. HL Xiang, Q Zhang, YK Han, L Yang, Y Zhang, Q Liu, ZR Zhang*, L Zhang*. Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment. Journal of Controlled Release, 2021, 335:498-514.
3. Y Fu, Q Lin, ZR Zhang*. Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis. Advances in Rheumatology, 2021,61(1):59.
4. XH Wang, M Li, KB Ren, CY Xia, JP Li, QW Yu, Y Qiu, ZZ Lu, Y Long, ZR Zhang*, Q He*. On-Demand Autophagy Cascade Amplification Nanoparticles Precisely Enhanced Oxaliplatin-Induced Cancer Immunotherapy. Advanced Materials, 2020, 32(32): 2002160.
5. Y Fu, Q Lin, ZR Zhang*, L Zhang*, Therapeutic strategies for the costimulatory molecule OX40 in T-cell mediated immunity. Acta Pharmaceutica Sinica B, 2020, 10(3):414-433.
6. X Cao, Y Hu, S Luo, YJ Wang, T Gong, X Sun, Y Fu*, ZR Zhang*. Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma. Acta Pharmaceutica Sinica B, 2019, 9(3): 575-589.
7. Q Wang, XY Zhang, HZ Liao, Y Sun, L Ding, YW Teng, WH Zhu*, ZR Zhang*, YR Duan*. Multifunctional Shell-Core Nanoparticles for Treatment of Multidrug Resistance Hepatocellular Carcinoma. Advanced Function Materials, 2018, 28(14):1706124.
8. KJ Jiang#, X Song#, LQ Yang, L Li, X Sun, T Gong, Q Lin*, ZR Zhang*. Enhanced antitumor and anti-metastasis efficacy against aggressive breast cancer with a fibronectin-targeting liposomal doxorubicin. Journal of Controlled Release, 2018, 271:21-30.
9. MK Qu, Q Lin, SS He, LY Wang, Y Fu, ZR Zhang*, L Zhang*. A brain targeting functionalized liposomes of the dopamine derivative N-3, 4-bis(pivaloyloxy)-dopamine for treatment of Parkinson's disease. Journal of Controlled Release, 2018, 277:173-182.
10. L Guo, S Luo, ZW Du, ML Zhou, PW Li, Y Fu, X Sun, Y. Huang, ZR Zhang*. Targeted delivery of celastrol by albumin nanoparticles to mesangial cells against glomerulonephritis. Nature Communications, 2017,8: 878.
11. XY Wang, BW Qi, HF Su, JB Li, X. Sun, Q He, Y Fu*, ZR Zhang*. Pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter for brain-specific drug delivery. Journal of Controlled Release, 2017,254:34-43.
12.S Luo, PW Li, S Li, ZW Du, X Hu, Y Fu*, ZR Zhang*. N, N-Dimethyl tertiary amino group mediated dual pancreas- and lung-targeting therapy against acute pancreatitis. Molecular Pharmaceutics, 2017,14(5):1771- 1781.
13. YC Zeng, S LI, C Liu, T Gong, X Sun, Y FU*, ZR Zhang*. Soluplus® micelles for improving oral bioavailability ofscopoletin and their hypouricemic effectin vivo. Acta Pharmacologica Sinica, 2017,38(3):424-433.
14. ML Zhou, JB Li, CH Li, LGuo, XY Wang, Q He, Y Fu*, ZR Zhang*. Tertiary amine mediated targeted therapy against metastatic lung cancer. Journal of Controlled Release, 2016;241:81-93.
15. X Song, ZY Wan, TJ Chen, Y Fu, KJ Jiang, XL Yi, H Ke, JX Dong, LQ Yang, L Li, X Sun, T Gong*, ZR Zhang*. Development of a Multi-Target Peptide for Potentiating Chemotherapy by Modulating Tumor Microenvironment. Biomaterials, 2016.108:44-56.
16. D Zheng, X Shuai, YP Li, P Zhou, T Gong, X Sun, ZR Zhang*. Novel flurbiprofen derivatives with improved brain delivery: Synthesis, in vitro and in vivo evaluation. Drug Delivery, 2016, 23(7):2183-2192,
17. HF Su, Q Lin, XY Wang, Y Fu, T Gong, X Sun, ZR Zhang*. Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms. Acta Pharmacologica Sinica, 2016;37:545-554.
18. Y Fu, Q Lin, T Gong, X Sun, ZR Zhang*. Mechanistic Studies of a Renal Targeted Triptolide-Glucosamine Conjugate with Lower toxicity and Superior Attenuation of Ischemia/Reperfusion Injury in Rats. Acta Pharmacologica Sinica,2016;37:1467-1480.
19.XW Wei*, S. Bin, ZY He, TH Ye, M Luo, YX Sang, X Liang, W Wang, ST Luo, SY Yang, CY Gong, ML Gou, HX Deng, YL Zhao, HS Yang, CJ Zhao, L Yang, ZY Qian, X Sun, JH Han, CY Jiang, S Zhang, M Wu, ZR Zhang*. Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response. Cell Research, 2015, 25:1-17.
20.JB Li, JJ Zhang, Y Fu, X Sun, T Gong, ZR Zhang*. Dual-specific targeting therapy mediated by a phenolic propanediamine moiety for local and systemic complications of acute pancreatitis. Journal of Controlled Release, 2015,212:19-29.
21.T Zhang#, Q Peng#, FY San, MX Wang, WQ Wu, T Gong*, ZR Zhang*. Sustained delivery of peptides and proteins by high content phospholipids-based phase separation gel. Biomaterials, 2015,45:1-9.
22.Q Wang, PF Liu, Y Sun, T Gong, MJ Zhu, X Sun, ZR Zhang*, YR Duan*. Preparation and properties of biocompatible PS-PEG/calcium phosphate nanospheres. Nanotoxicology, 2015, 9:190.
23.Y. Cheng, BY Zhu, Y Deng, ZR Zhang*. In Vivo detection of cerebral amyloid fibrils with smart dcm-based fluorescence probe. Analytical Chemistry, 2015, 87:4781-4787.
24.YP Li, YY Zhou, JY Jiang, XY Wang, Y Fu, T Gong, X Sun, ZR Zhang*. Brain-targeting mechanism of dexibuprofen prodrugs modified with ethanolamine-related structures. Journal of Cerebral Blood Flow and Metabolism, 2015, 35:1985-1994.
25.Q Lin, Y Fu, J Li, MK Qu, L Deng, T Gong*, ZR Zhang*. A (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer)-dispersed sustained-release tablet for imperialine to simultaneously prolong the drug release and improve the oral bioavailability. European Journal of Pharmaceutical Science, 2015,79:44-52.
