Qin He Professor Doctoral supervisor
Contact Information:
Mail Address: No.17, Section 3, South Renmin Road, Chengdu, China, 610041
Telephone/Fax: +86 (28) 85502532
E-mail: qinhe317@126.com
Website of the research group: http://www.qinhegroup.com
Education:
2007 to present Professor, doctoral supervisor, West China School of Pharmacy, Sichuan University
2002-2007 Associate professor, West China School of Pharmacy, Sichuan University
2000-2003 Researcher, Korean Kolmar Pharmaceutical Research Institute
2000-2003 Ph.D. degree in Pharmaceutics, West China School of Pharmacy, Sichuan University
1994-1997 M.S. degree in Pharmaceutics, School of Pharmacy, West China University of Medical Science
1984-1989 B.S. degree in medical chemistry, School of Pharmacy, West China University of Medical Science
Visted and studied at Arizona State University and University of California, Long Beach
Research Interest:
1. Research on efficient tumor targeting and anti-metastasis drug delivery system
(1) Nanodrug delivery system regulating tumor microenvironment
(2) Anti-tumor drug delivery system based on autophagy regulation
(3) Multi-site anti-tumor and anti-metastasis nanodrug delivery system
2. Research on targeted drug delivery system for inflammation
3. Research on bionic drug delivery system
4. Research on efficient nucleic acid drug delivery system
Appointment：
2017 to present Vice Dean, West China School of Pharmacy, Sichuan University
2007-2017 Chief of Department of Pharmaceutics, West China School of Pharmacy, Sichuan University
Academic part-time job:
1. Vice Chairman of Pharmaceutical Committee of Chinese Pharmaceutical Association (2012-2019)
2. Vice Chairman of the Biological Particles Committee of the Chinese Society of Granular Science Association
3. Executive Director, China Branch, International Association for Controlled Release
4. Member of the Pharmaceutical Teaching Reference Committee of the Ministry of Education and Chairman of the Pharmaceutical Teaching Reference Committee of Sichuan Province
5. Associate editor of European Journal of Pharmaceutics and Biopharmaceutics
6. Associate editor of Pharmaceutical Fronts
7. Editorial board member of Asian Journal of Pharmaceutics Sciences/Pharmaceutica Sinica/ Journal of Sichuan University Medical Science Edition /Chinese Journal of Pharmaceutical Industry/Chinese Journal of Antibiotics
8. Chief Editor of Pharmacy, Higher Education Press
9. Chief Editor of New Pharmaceutical Experiments, Sichuan University Press
10. Associate Editor of Pharmacy, Chinese Medical Encyclopedia, Peking Union Medical College Press
11. Deputy Editor of Cosmetic Pharmacology, People's Medical Publishing House
Awards:
1. Medical Journal of Sichuan University special allowance expert of The State Council, young and middle-aged experts with outstanding contributions to national health and family planning
2. New Century Talents of the Ministry of Education
3. Academic and Technical Leader of Sichuan Province
4. "Tianfu Qingcheng Plan" Tianfu Leading talents in science and technology
5. Leading health talents of Sichuan Province
6. Winner of Sichuan Outstanding Youth Fund
7. The Second Prize of Science and Technology Progress of Sichuan Province in 2020 (Natural Science) (the 1st Accomplisher)
8. The First Prize of Science and Technology Progress of Sichuan Province in 2011 (the 4th Accomplisher)
9. The First Prize of Science and Technology Progress of Sichuan Province in 1999 (the 3rd Accomplisher)
10. The Second Prize of Science and Technology Progress of Sichuan Province in 2020 (Natural Science) (the 1st Accomplisher)
11. The Second Prize of Science and Technology Progress Award of Chongqing in 2001 (the 2nd Accomplisher)
12. The Third Prize of Science and Technology Progress of Sichuan Province in 2006 (the 3rd Accomplisher)
13. The Third Prize of Science and Technology of the Chinese Association of Traditional Chinese Medicine in 2003 (the 2nd Accomplisher)
14. The Third Prize of the Science and Technology Progress Award of the Ministry of Education in 1998 (the 3rd Accomplisher)
15. The first Prize of Teaching Achievements of Sichuan University in 2016 (the 1st Accomplisher)
16. The third prize of the 8th Higher Education Excellent Teaching Achievement of Sichuan Province in 2018 (the 2nd Accomplisher)
17. The third Prize of the 8th Higher Education Excellent Teaching Achievements of Sichuan Province in 2018 (the 1st Accomplisher)
18. 2011 Excellent Master's Thesis Advisor of Sichuan Province
19. 2013 Excellent Master's Thesis Advisor of Sichuan Province
20. Excellent doctoral thesis Advisor of Sichuan University in 2021
21. Excellent Master thesis Advisor of Sichuan University in 2021
22. "Outstanding Young Teacher" of Chengdu
23. The first "Spark Alumni Award" of Sichuan University, Excellent Teacher of Sichuan University, Top Ten Teacher Mentoring Award of Sichuan University
24. The Gold Award instructor of the 7th China International "Internet Plus" College Student Innovation and Entrepreneurship Competition National Finals International Circuit
25. Instructor of the Bronze Award of the 6th China International "Internet Plus" College Student Innovation and Entrepreneurship Competition National Finals International Circuit
26. Instructor of the National Silver Award of the 5th National Finals of China "Internet Plus" College Students' Innovation and Entrepreneurship Competition
27. Gold Award instructor of Sichuan Province in the 5th China "Internet Plus" College Student Innovation and Entrepreneurship Competition
28. Instructor of Gold Award of the 4th Sichuan Province "Internet Plus" College Student Innovation and Entrepreneurship Competition
Major research projects in recent 5 years：
1. National Key Basic Research and Development Program (973 Program), Research on key technologies of engineering preparation of targeted nanomedicine for brain tumor system, 2013.1-2017.8, 5.57 million Yuan
2. Design Principle and construction mechanism of efficient delivery system of biomolecular Drugs in Major Project of National Natural Science Foundation of China, 2017.1-2021.12, 3.326 million Yuan (Participated)
3. Research on "Step by Step Ship" nano drug delivery system based on activation of autophagy of tumor draining lymph node, National Natural Science Foundation of China, 2022.1-2025.12, 550,000 Yuan
4. Research on multi-site nanoscale self-transmitting micelles to prevent metastasis and recurrence after tumor surgery, National Natural Science Foundation of China, 2020.1-2023.12, 550,000 Yuan
5. Research on variable particle size nano drug delivery system targeting orthotopic tumors and lymphatic metastases with high efficiency, National Natural Science Foundation of China, 2018.1-2021.12, 635,000 Yuan
6. Construction and evaluation of nano delivery system based on intelligent particle size regulation and programmed release of autophagy inhibitors and chemotherapeutic drugs of National Natural Science Foundation of China, 2016.1-2019.12, 771,000 Yuan
7. Construction and evaluation of liposome drug delivery system based on "one multi-effect" target head efficiently crossing tumor drug delivery barrier, National Natural Science Foundation of China, 2014.1-2017.12, 850,000 Yuan
8. Key Project of Applied Basic Research of Sichuan Province 2022-2024, 400,000 Yuan
9. Demonstration Project of Transfer and Transformation of Scientific and Technological Achievements of Sichuan Province, 2022.1-2023.12, 800,000 Yuan (major participant)
10. Demonstration Project of Transfer and Transformation of Scientific and Technological Achievements of Sichuan Province, 2021.4-2023.3, 2 million Yuan (major participant)
11. Sichuan Innovation Talent Fund, 2018.7-2020.7, 300,000 Yuan
12. Veterinary Drug Innovation Team of Sichuan Department of Agriculture -- Veterinary Chemical Drug Research, 2018-2022, 500,000
13. Transformation of concentrated solution for sodium valproate Injection in Sichuan University-Luzhou Strategic Cooperation Project 2021-2024, 800,000 Yuan
14. Medical and Industrial Integration Innovation Project of Medical + Materials Center, Sichuan University, 2022.1-2022.12, 600,000 Yuan
Selected Publications:
1. Xuhui Wang, Man Li, Kebai Ren, Chunyu Xia, Jianping Li, Qianwen Yu, Yue Qiu, Zhengze Lu, Yang Long, Zhirong Zhang*, Qin He*. On-Demand Autophagy Cascade Amplification Nanoparticles Precisely Enhanced Oxaliplatin-Induced Cancer Immunotherapy. Advanced Materials, 2020, 2002160. IF=30.849
2. Xian Tang, Qinglin Sheng, Chaoqun Xu, Man Li, Jingdong Rao, Xuhui Wang, Yang Long, Yuan Tao, Xuan He, Zhirong Zhang, Qin He*. pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy. Nano Today, 2021, 37, 10108. IF=20.722
3. Yang Long, Zhengze Lu, Ling Mei, Man Li, Kebai Ren, Xuhui Wang, Jiajing Tang, Zhirong Zhang, Qin He*. Enhanced Melanoma-Targeted Therapy by “Fru-Blocked” Phenyboronic Acid-Modified Multiphase Antimetastatic Micellar Nanoparticles. Advanced Science, 2018, 5(11), 1800229. IF=16.806
4. Yang Long, Zhengze Lu, Shanshan Xu, Man Li, Xuhui Wang, Zhirong Zhang, Qin He*. Self-Delivery Micellar Nanoparticles Prevent Premetastatic Niche Formation by Interfering with the Early Recruitment and Vascular Destruction of Granulocytic Myeloid-Derived Suppressor Cells. Nano Letters, 2020, 20, 4, 2219-2229. IF=11.189
5. Yang Wang, YueQiu, Sheng Yin, Li Zhang, Kairong Shi, HuileGao, Zhirong Zhang and Qin He*. A functional nanocarrier that co-penetrates extracellular matrix and multiple layers of tumorcells for sequential and deep tumor autophagy inhibitor and chemotherapeutic delivery. Autophagy, 2017, 13, 2, 359–370. IF=16.016
6. Yang Wang, Kairong Shi, Li Zhang, Guanlian Hu, Jingyu Wan, Jiajing Tang, Sheng Yin, Jiandong Duan, Ming Qin, Neng Wang, Dandan Xie, Xinle Gao, Huile Gao, Zhirong Zhang, Qin He*. Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin. Autophagy, 2016, 12(6):1–14. IF=16.016
7. Junyu Wu, Yang Long, Man Li*, Qin He*. Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”. Acta Pharmaceutica Sinica B, 2021,11(8), 2286-2305. IF=14.90.
8. Rong Guo, Miao Deng, Xuan He, Mengmeng Li, Jiaxin Li, Penghui He, Houqin Liu, Man Li, Zhirong Zhang, Qin He*. Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment. Acta Pharmaceutica Sinica B, 2022, 12(1), 467-482. IF=14.90.
9. Yang Wang, Sheng Yin, Li Zhang, Kairong Shi, Jiajing Tang, Zhirong Zhang, Qin He*. A tumor-activatable particle with antimetastatic potential in breast cancer via inhibiting the autophagy-dependent disassembly of focal adhesion. Biomaterials, 2018, 168, 1-9. IF=12.479
10. ShaoboRuan, Mingqing Yuan, Li Zhang, Guanlian Hu, Jiantao Chen, XingliCun, Qianyu Zhang, Qin He* and HuileGao*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37:425-435. IF=12.479
11. Yayuan Liu, Rui Ran, Jiantao Chen, QifangKuang, Jie Tang, Ling Mei, Qianyu Zhang, HuileGao, Zhirong Zhang, Qin He*. Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials, 2014, 35:4835-4847. IF=12.479
12. Qianyu Zhang, Jie Tang, Ling Fu,Rui Ran, Yayuan Liu,Mingqing Yuan, Qin He*. A pH-responsive -helical cell penetrating peptide-mediated liposomal delivery system. Biomaterials, 2013,34(32):7980-7993. IF=12.479
13. Xiaoxiao Chen#, Yuan Tao#, Manmin He, Miao Deng, Rong Guo, Qinglin Sheng, Xuhui Wang, Kebai Ren, Ting Li, Xuan He, Shuya Zang, Zhirong Zhang, Man Li* and Qin He*. Co-delivery of autophagy inhibitor and gemcitabine using a pH-activatable core-shell nanobomb inhibits pancreatic cancer progression and metastasis. Theranostics 2021, 11, 18, 8692-8705. IF=11.556
14. Dandan Wan, Yiliang Yang, Yiyao Liu, Xingli Cun, Man Li, Shanshan Xu, Wei Zhao, Yangyang Xiang, YueQiu, Qianwen Yu, Xian Tang, Zhirong Zhang, Qin He*. Sequential Depletion of Myeloid-derived Suppressor Cells and Tumor Cells with a Dual-pH-Sensitive Conjugated Micelle System for Cancer Chemoimmunotherapy. Journal of Controlled Release, 2020, 317, 43-56. IF=11.467
15. Man Li, Mengmeng Li, Yiliang Yang, Yingke Liu, Hanbing Xie, Qianwen Yu, Lifeng Tian, Xian Tang, Kebai Ren, Jianping Li, Zhirong Zhang, Qin He*. Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy. Journal of Controlled Release, 2020, 321, 23-35. IF=11.467
16. Yashi Wang, Sheng Yin, Lin Mei, Yiliang Yang, Shanshan Xu, Xuan He, Mou Wang, Man Li, Zhirong Zhang, Qin He⁎ A dual receptors-targeting and size-switchable “cluster bomb” co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer. Journal of Controlled Release, 2020, 321, 71-83. IF=11.467
17. Qianwen Yu, Yue Qiu, Jianping Li, Xian Tang, Xuhui Wang, Xingli Cun, Shanshan Xu, Yayuan Liu, Man Li, Zhirong Zhang, Qin He*. Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy. Journal of Controlled Release, 2020, 321, 564-575. IF=11.467
18. Xuhui Wang, Sheng Yin, Man Li, Jingdong Rao, Dandan Wan, Yue Qiu, Qianwen Yu, Xiaoxiao Chen, Zhengze Lu, Yang Long, Zhirong Zhang, Qin He*. Autophagy inhibition changes the disposition of non-viral gene carriers during blood-brain barrier penetration and enhances TRAIL-induced apoptosis in brain metastatic tumor. Journal of Controlled Release, 2020, 321, 497-508. IF=11.467
19. Man Li, Hanbing Xie, Yingke Liu, Chunyu Xia, Xingli Cun, Yang Long, Xiaoxiao Chen, Miao Deng, Rong Guo, Zhirong Zhang, Qin He*. Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer. Journal of Controlled Release, 2019, 304, 204-215. IF=11.467
20. Sheng Yin, Chunyu Xia, Yashi Wang, Dandan Wan, Jingdong Rao, Xian Tang, Jiaojie Wei, Xuhui Wang, Man Li, Zhirong Zhang, Ji Liu⁎, Qin He*. Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways. Journal of Controlled Release, 2018, 288, 148–160. IF=11.467
