Dapeng Li
PhD, Associate Professor
Correspondence: West China School of Pharmacy, Sichuan University, No. 17, Section 3, Renmin South Road, Chengdu, China (610041)
Emails: dpli@scu.edu.cn, dpli_dapengli@hotmail.com
Education and work experience:
2021.03-Present, West China School of Pharmacy, Sichuan University, Department of Pharmaceutical Analysis, Associate Professor
2018.07-2020.12, Hong Kong Baptist University, Department of Chemistry, Postdoctoral
2017.02-2017-03, Stanford University/University of the Pacific, USA, Visiting Fellowship
2015.07-2015.08, University of Hong Kong, Li Ka Shing Faculty of Medicine, Visiting Fellowship
2013.9-2018.6, China Pharmaceutical University, School of Traditional Chinese Medicine, PhD
2009.9-2013.6, China Pharmaceutical University, School of Traditional Chinese Medicine, B.S.
Research Fields:
1. Proteomics and PTMomics-based drug mechanism of action and target discovery
2. Novel analytical techniques and methods based on functional nanochemistry
3. Quality control and analysis of drugs / natural products
Research Projects:
1. Multi-omics-based strategies of drug intervention and therapeutic mechanism discovery of clinical metabolic disease, Talent Research Fund of Sichuan University, 2021.3-2024.3, PI
2. The mechanism of actions of celastrol via regulating metabolic homeostasis to alleviate the NASH, NSFC Young Scientist Fund, 2023-2025, PI
3. Development of the novel high-throughput method for glycoproteomic analysis and its application in metabolic diseases, Innovation guidance fund of the Key laboratory of targeted drugs and drug delivery system of the Ministry of Education, 2022-2023, PI
Represent Publications:
(1) Gong, P.; Yin, K.; Luo, X.; Gu, J.; Tan, R.; Wu, Y.; Li, D. Tandem Mass Tag-Based Proteomics Analysis Reveals the Multitarget Mechanisms of Phyllanthus Emblica against Liver Fibrosis. Frontiers in Pharmacology 2022, 13.
(2) Li, D.; Jiang, L.; Hong, Y.; Cai, Z. Multilayered Glycoproteomic Analysis Reveals the Hepatotoxic Mechanism in Perfluorooctane Sulfonate (PFOS) Exposure Mice. Environmental Pollution 2021, 268, 115774.
(3) Li, D.; Zhang, J.; Xie, G.; Ji, F.; Shao, X.; Zhu, L.; Cai, Z. A Dual-Zwitterion Functionalized Ultra-Hydrophilic Metal–Organic Framework with Ingenious Synergy for Enhanced Enrichment of Glycopeptides. Chem. Commun. 2019, 55 (93), 13967–13970.
(4) Yang, C.; Zhu, L.; Kang, Q.; Lee, H. K.; Li, D.; Chung, A. C. K.; Cai, Z. Chronic Exposure to Tetrabromodiphenyl Ether (BDE-47) Aggravates Hepatic Steatosis and Liver Fibrosis in Diet-Induced Obese Mice. Journal of Hazardous Materials 2019, 378, 120766.
(5) Li, D.; Xu, L.; Qi, J.; Yu, B. Screening and Analysis of Cyclooxygenase-2 Inhibitors from the Complex Matrix: A Case Study to Illustrate the Important Effect of Immobilized Enzyme Activity in Magnetic Ligand Fishing. Journal of Pharmaceutical and Biomedical Analysis 2019, 175, 112795.
(6) Yi, R.; Fu, R.; Li, D.; Qi, J.; Liu, H. Identification of Ligands from Natural Products as Inhibitors of Glutathione S-Transferases Using Enzyme Immobilized Mesoporous Magnetic Beads with High-Performance Liquid Chromatography plus Quadrupole Time-of-Flight Mass Spectrometry and Molecular Docking. Journal of Separation Science 2019, 42 (24), 3611–3620.
(7) Wang, Y.; Hong, F.; Li, D.; Qi, J.; Liu, X. A Novel Strategy for Evaluation of Natural Products Acting on the Myeloperoxidase/Hypochlorous Acid System by Combining High-Performance Liquid Chromatography-Photodiode Array Detection-Chemiluminescence and Ultrafiltration-Mass Spectrometry Techniques. Journal of Separation Science 2018, 41 (22), 4222–4232.
(8) Wang, T.; Li, D.; Yu, B.; Qi, J. Screening Inhibitors of Xanthine Oxidase from Natural Products Using Enzyme Immobilized Magnetic Beads by High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. Journal of Separation Science 2017, 40 (9), 1877–1886.
(9) Li, D.; Yi, R.; Tian, J.; Li, J.; Yu, B.; Qi, J. Rational Synthesis of Hierarchical Magnetic Mesoporous Silica Microspheres with Tunable Mesochannels for Enhanced Enzyme Immobilization. Chem. Commun. 2017, 53 (63), 8902–8905.
(10) Li, D.; Wang, T.; Guo, Y.; Hu, Y.; Yu, B.; Qi, J. Online Screening of Nitric Oxide Scavengers in Natural Products Using High Performance Liquid Chromatography Coupled with Tandem Diode Array and Fluorescence Detection. Journal of Chromatography A 2015, 1425, 106–115.
(11) Li, F.; Tan, Y.-S.; Chen, H.-L.; Yan, Y.; Zhai, K.-F.; Li, D.-P.; Kou, J.-P.; Yu, B.-Y. Identification of Schisandrin as a Vascular Endothelium Protective Component in YiQiFuMai Powder Injection Using HUVECs Binding and HPLC-DAD-Q-TOF-MS/MS Analysis. Journal of Pharmacological Sciences 2015, 129 (1), 1–8.
